Pasar al contenido principal
  • Socios aprobados
  • Acerca de ELGA
    • Acerca de ELGA
    • Empleo
    • Eventos
  • Soporte
    • Planificación de laboratorio
    • Registrar un producto
    • Register Your Product (USA & Canada Only)
  • Contacto
  • U.S.A.
  • U.K.
  • Deutschland
  • France
  • Italia
  • Brasil
  • 日本
  • 中国
Inicio ELGA LabWater
  • Productos
    • PURELAB
    • CENTRA
    • MEDICA
    • BIOPURE
    • Gama completa de productos ELGA
  • Aplicaciones
    • Análisis microbiológico
    • Bioquímica clínica
    • Cromatografía de gases
    • Cromatografía líquida
    • Cultivos celulares
    • Electroquímica
    • Espectrofotometría
    • Espectrometría de masas
    • Espectroscopia atómica
    • Genética
    • Inmunoquímica
    • Requisitos generales de agua de laboratorio
  • Tecnologías
    • Carbón activado
    • Electrodesionización (EDI)
    • Filtración
    • Intercambio iónico
    • PureSure
    • Ultravioleta
    • Ósmosis inversa
  • Impurezas en el agua
    • Compuestos inorgánicos
    • Compuestos orgánicos
    • Gases disueltos
    • Microorganismos y bacterias
    • Partículas
  • Knowledge
    • Blog
    • Casos prácticos
    • Agua ultrapura
    • Manuales e informes técnicos
  • Productos
    • PURELAB
    • CENTRA
    • MEDICA
      • Hubgrade
      • MEDICA BIOX
    • BIOPURE
    • Gama completa de productos ELGA
      • PURELAB® Classic
  • Aplicaciones
    • Análisis microbiológico
    • Bioquímica clínica
    • Cromatografía de gases
    • Cromatografía líquida
      • Hochleistungsflüssigkeitschromatographie (HPLC)
    • Cultivos celulares
    • Electroquímica
    • Espectrofotometría
    • Espectrometría de masas
    • Espectroscopia atómica
    • Genética
    • Inmunoquímica
    • Requisitos generales de agua de laboratorio
  • Tecnologías
    • Carbón activado
    • Electrodesionización (EDI)
    • Filtración
    • Intercambio iónico
    • PureSure
    • Ultravioleta
    • Ósmosis inversa
  • Impurezas en el agua
    • Compuestos inorgánicos
    • Compuestos orgánicos
    • Gases disueltos
    • Microorganismos y bacterias
    • Partículas
  • Knowledge
    • Blog
      • Analytical Chemistry
      • Clinical & Pharma
      • Cool Science
      • Environment and sustainability
      • Life in the lab
      • Purelab product design
      • Science of the future
      • Water Purity
      • Water in the lab
    • Casos prácticos
      • Abbott Diagnostics elige sistemas ELGA MEDICA en el sur de Asia
      • Beam Me Up, Scotty: PURELAB® Option Q Delivers Essential Ultra Pure Water
      • Argenta chooses DKSH New Zealand to deliver Ultrapure water in Animal Pharma
      • Clean Water for a Clean Future
      • LS Scientific & ELGA deliver UltraPure water to the NAFDAC Laboratory
      • Lifebrain Group chooses ELGA as water partner for new modern 24/7 PCR-COVID-19 laboratory in Vienna, Austria.
      • Critital Tests Benefit from PURELAB® Option Reliable Pure Water
      • DASA: la mayor empresa de diagnóstico médico de Brasil
      • ELGA ayuda a los laboratorios de inmunoserología a maximizar el tiempo de actividad
      • Fondazione Telethon Continues to Choose ELGA Labwater as a Trusted Partner
      • La importancia del agua ultrapura de tipo 1+ para el desarrollo de medicamentos genéricos
      • Seleccionan MEDICA® Pro para los analizadores Siemens ADVIA® del City General Hospital
      • Optimale Wasserqualität für mikrobiologische Forschung und Lehre
      • PURELAB® Option R Guarantees Pure Water for Leading Microfluidics Technology
      • PURELAB® Pulse Delivers Reliable Water Quality and Quantity for a Wide Range of Applications
      • PURELAB® flex: un sistema de formación ideal para el método de investigación actual
      • Powering Cutting-Edge Gene Research
      • Sichere Reinstwasserversorgung für präzise Produkttests
      • Zentrale Reinstwasser-Aufbereitung für Analyser
      • ELGA LabWater and Beckman Coulter Join Forces
      • Applied New Technologies Department Improves ICP, IC & HPLC Sample Turnaround Times with PURELAB®
      • Descubrir los secretos de la Antártida con ayuda del agua ultrapura
      • Advancing Genetic Technologies
      • Cross Infection Control: Pure and Simple
      • Researching effective new ways to prevent cardiovascular disease at the University of Columbia
    • Agua ultrapura
    • Manuales e informes técnicos
      • Pureza de agua de HPLC
      • HPLC en farmacia
      • Reducción del riesgo clínico
      • Sostenibilidad
  • U.S.A.
  • U.K.
  • Deutschland
  • France
  • Italia
  • Brasil
  • 日本
  • 中国
  • Política de privacidad
  • Términos y condiciones
  • Cumplimiento legal internacional
  • Patentes
  • Aviso legal
  • Inicio
  • Purified Water In Clinical Diagnostic Testing
Clinical & Pharma
Water Purity

Purified Water In Clinical Diagnostic Testing

31 Ene 2020
- by ELGA Editorial Team

Pipette dripping ultrapure water sample into test tube

Detecting Cancer with a Drop of Pure Water

Did you know that we can now detect cancer using a drop of pure water? And that water quality can influence the development of novel medicines?

We at ELGA LabWater have been amazed to discover just how important pure water is in clinical diagnostics. It is not only playing an increasingly crucial role in the development of innovative clinical diagnostic tests, but it is also helping to advance the emerging field of precision medicine. Below we look at how harnessing the power of pure water in clinical diagnostics has the potential to transform patient health.

How is Purified Water Helping to Enhance Clinical Diagnostics?       

As laboratory water purification experts, here at ELGA LabWater, we are excited by the increasing number of innovative clinical diagnostic technologies that are harnessing the properties of purified water. For example, pure water is a critical aspect of a novel interoperative technology for cancer surgery, called the MasSpec Pen. (1) 

Innovative Clinical Diagnostic Testing Technologies

This recently developed handheld, disposable ionization device releases a discrete droplet of pure water onto suspected cancer tissue. The molecular content of the water droplet is then analyzed by a connected mass spectrometer to determine if the biomolecular profile matches that of cancerous tissue. 

Most significantly, the results are generated within just ten seconds, allowing surgeons to identify accurately the tumor’s boundaries in real-time; that is, which is the cancerous tissue to remove and which is the healthy tissue to leave behind. This improves on previous methods that are time-consuming and labor-intensive (e.g. imaging, cryo-preservation, and microscopic analysis), helping to improve the outcome for patients by reducing the time they spend on the operating table and minimizing the need for follow-up procedures.

A Drop of Pure Water is Critical in Clinical Diagnostics

The water droplet that extracts the tissue’s molecular content must use purified water for a number of reasons. First, using pure water avoids the risk of impurities interfering with the molecular profiling of the cancerous tissue. In fact, the research team who developed this mass spec-based device found that using pure water generated much clearer molecular profiles of the tissue compared to previously tested substances (ethanol and ethanol-water mixes). (2)

Second, pure water enables the chemical extraction of low molecular weight compounds, such as metabolites and lipids, from the tissue. Finally, pure water is bio-compatible with humans, so this device is well-suited to in vivo analysis as it doesn’t harm the tissue, unlike other ambient ionization techniques that damage or destroy the target tissue. 

ELGA LabWater’s Role in Precision Clinical Diagnostics

Precision medicine is an emerging field that is transforming healthcare and drug development and relies on clinical diagnostic tests, of which water purification systems are an integral part. For example, biomarkers associated with diseases in patients are now being increasingly monitored by drug developers to predict which patients will respond favorably to treatments, speeding up clinical trials and making new drugs more rapidly available to patients at a reduced cost. 

Such patient biomarker profiling typically relies on diagnostic techniques, such as liquid chromatography-mass spectrometry (LC-MS), but the quality of the data generated by these tests is dependent on the water quality used. That's because poor quality water can contain impurities, including organics, ions, bacteria, or particulates that can reduce the accuracy of the data generated by mass spectrometry and liquid chromatography, such as loss of resolution, ghost peaks, and shifts in retention times. 

Therefore, high-grade ultrapure water supplied by water purification systems, such as ELGA LabWater’s PURELAB® range (3), can ensure the reliability of biomarker profiles, helping to increase success rates of clinical trials and enable patients to receive potentially life-changing treatments.

Home Diagnostic Testing – Help or a Hindrance?

The emergence of precision medicine has accompanied the development of a booming home diagnostic testing kit market, comprising self-screening kits for a huge variety of conditions ranging from infertility to HIV. Experts are in two minds about these DIY diagnostic tests – they could mark a new medical era or just be a risk to our health. (4)

On the one hand, they have the potential to deliver affordable diagnostic kits to people with little or no access to medical care in the developing world; but on the other hand, removing diagnostic tests from the professional clinical laboratory risks misleading and unreliable results. As such, the current regulatory advice is to ensure that home diagnostic kits are always supplemented by controlled tests in a clinical laboratory, where state-of-the-art analytical technologies and clinical-grade ultrapure water can ultimately ensure patient health isn’t compromised.

With such remarkable initiatives and innovations being developed in clinical diagnostics, it is clear to us at ELGA LabWater that this is an incredibly exciting time for the application of purified laboratory water as a biomedical tool.   

References

[1] https://eberlin.cm.utexas.edu/masspec-pen
[2] https://www.360dx.com/molecular-diagnostics/ut-team-develops-mass-spec-based-device-guiding-cancer-surgery
[3] https://www.elgalabwater.com/products/purelab
[4] https://www.elgalabwater.com/blog/home-diagnostic-testing-kits-new-medical-era-or-risk-our-health

 

Troubleshooting Guide

Blast your problems out of the water...

Find out how to troubleshoot your application problems with our troubleshooting guide

             Download Now

 

  • Enquiry
  • Consigue una cotización
  • Reserve una demo
  • Encuentre un socio aprobado

Enquiry

Please check this to confirm that you have read our Terms of Service and Privacy Policy.

Consigue una cotización

Please check this to confirm that you have read our Terms of Service and Privacy Policy.

Reserve una demo

Please check this to confirm that you have read our Terms of Service and Privacy Policy.

Call us

Can't find what you are looking for?

Support Number
+44 (0)20 3567 7300
United Kingdom Sales
+44 (0)1628 879 704
United States of America Sales
+1 877-315-3542
France Sales
+33 1 40 83 65 00
China Sales
+86 400-616-8882

 

ELGA LabWater US Headquarters

Lane End Business Park
Lane End, High Wycombe
HP14 3BY
Reino Unido
Tel.: +44 (0) 203 567 7300
F: +44 (0) 203 567 7205

Sede central de ELGA LabWater

Lane End Business Park
Lane End, High Wycombe
HP14 3BY
Reino Unido
Tel.: +44 (0) 203 567 7300
F: +44 (0) 203 567 7205

Casos prácticos

  • Abbott Diagnostics
  • Diagnóstico médico de DASA
  • Instituto Médico NeoDIN
  • Fundación del NHS de North Staffordshire
  • Escuela técnica de Olsberg

Recursos

  • Obtenga más información sobre el agua ultrapura
  • Manuales e informes técnicos
  • Tecnologías de purificación
  • Aplicaciones
  • Impurezas en el agua

Blogs

  • Latest Blog
  • Water Purity - Different Types of Pure Water
  • What is Clinical Laboratory Reagent Water (CLSI)?
  • What is Total Organic Carbon (TOC)?
  • Idioma
    • Deutsch
    • English
    • Español
    • Français
    • Italiano
    • Português
    • 日本語
    • 中文
  • Otros sitios de Veolia
    • Veolia
    • Veolia Foundation
    • Veolia Water Technologies

© VWS (UK) Ltd. comercializado como ELGA LabWater.2023-Todos los derechos reservados.
ELGA es la marca mundial de agua de laboratorio de Veolia.

  • Política de privacidad
  • Términos y condiciones
  • Cumplimiento legal internacional
  • Patentes
  • Aviso legal
Elga Veolia
TOP

© 2017 ELGA Veolia